C.F. Shen

Latest

• Optimization and scale-up of cell culture and purification processes for production of an adenovirus-vectored tuberculosis vaccine candidate
• Influence of HEK293 metabolism on the production of viral vectors and vaccine
• Hyperosmotic pressure on HEK 293 cells during the growth phase, but not the production phase, improves adenovirus production
• Process optimization and scale-up for production of rabies vaccine live adenovirus vector (AdRG1.3)
• Reassessing culture media and critical metabolites that affect adenovirus production
• Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production
• Micro-quantitation of lipids in serum-free cell culture media: A critical aspect is the minimization of interference from medium components and chemical reagents
• Quantitation of baculovirus particles by flow cytometry