D. Jacob

Latest

• Optimization and scale-up of cell culture and purification processes for production of an adenovirus-vectored tuberculosis vaccine candidate
• Process optimization and scale-up for production of rabies vaccine live adenovirus vector (AdRG1.3)
• Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture
• Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing
• An efficient and scalable process for helper-dependent adenoviral vector production using polyethylenimine-adenofection
• Development of a simple and high-yielding fed-batch process for the production of influenza vaccines
• Development of a suspension serum-free helper-dependent adenovirus production system and assessment of co-infection conditions
• High yield purification of functional baculovirus vectors by size exclusion chromatography
• Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells
• Virus-like particle and viral vector production using the baculovirus expression vector system/ insect cell system: Adeno-associated virus-based products
• Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: From shake flasks to a 20-L bioreactor
• Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus
• 293SF metabolic flux analysis during cell growth and infection with an adenoviral vector
• On-line measurement of green fluorescent protein (GFP) fluorescence for the monitoring of recombinant adenovirus production