Selected Publications

1. Influence of HEK293 metabolism on the production of viral vectors and vaccine.

Vaccine. 2015; PubMed [journal] PMID: 26073013

2. Critical assessment of influenza VLP production in Sf9 and HEK293 expression

systems. BMC biotechnology. 2015; 15:31. PubMed [journal] PMID: 25981500

3. Large-scale adenovirus and poxvirus-vectored vaccine manufacturing to enable

clinical trials. Biotechnology journal. 2015; 10(5):741-7. PubMed [journal] PMID:


4. Current and emerging cell culture manufacturing technologies for influenza

vaccines. BioMed research international. 2015; 2015:504831. PubMed [journal]

PMID: 25815321

5. Particle quantification of influenza viruses by high performance liquid

chromatography. Vaccine. 2015; 33(1):78-84. PubMed [journal] PMID: 25448111

6. Establishment and validation of new complementing cells for production of

E1-deleted adenovirus vectors in serum-free suspension culture. Journal of

virological methods. 2014; 208:177-88. PubMed [journal] PMID: 25159033

7. Development of a vectored vaccine against hepatitis E virus. Vaccine. 2014;

32(24):2808-11. PubMed [journal] PMID: 24583005

8. Evaluation of homogeneity and genetic stability of REOLYSIN (pelareorep) by

complete genome sequencing of reovirus after large scale production. Applied

microbiology and biotechnology. 2014; 98(4):1763-70. PubMed [journal] PMID:


9. Production of adeno-associated virus (AAV) serotypes by transient transfection

of HEK293 cell suspension cultures for gene delivery. Journal of virological

methods. 2014; 196:163-73. PubMed [journal] PMID: 24239634

10. Analytical technologies for influenza virus-like particle candidate vaccines:

challenges and emerging approaches. Virology journal. 2013; 10:141. PubMed

[journal] PMID: 23642219

11. Real-time monitoring of influenza virus production kinetics in HEK293 cell

cultures. Biotechnology progress. 2013; 29(1):275-84. PubMed [journal] PMID:


12. . Probing inhibitory effects of nanocrystalline cellulose: inhibition versus

surface charge. Nanoscale. 2012; 4(4):1373-9. PubMed [journal] PMID: 22252333

13. Process optimization and scale-up for production of rabies vaccine live

adenovirus vector (AdRG1.3). Vaccine. 2012; 30(2):300-6. PubMed [journal] PMID:


14. A novel polyethyleneimine-coated adeno-associated virus-like particle

formulation for efficient siRNA delivery in breast cancer therapy: preparation

and in vitro analysis. International journal of nanomedicine. 2012; 7:1575-86.

PubMed [journal] PMID: 22619514

15. Hyperosmotic pressure on HEK 293 cells during the growth phase, but not the

production phase, improves adenovirus production. Journal of biotechnology. 2012;

157(1):228-36. PubMed [journal] PMID: 22154564

16. Transient transfection of serum-free suspension HEK 293 cell culture for

efficient production of human rFVIII. BMC biotechnology. 2011; 11:114. PubMed

[journal] PMID: 22115125

17. Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis.

Bioprocess and biosystems engineering. 2011; 34(3):263-73. PubMed [journal] PMID:


18. Insect cell technology is a versatile and robust vaccine manufacturing

platform. Expert review of vaccines. 2011; 10(7):1063-81. PubMed [journal] PMID:


19. An initiative to manufacture and characterize baculovirus reference material.

Journal of invertebrate pathology. 2011; 107 Suppl:S113-7. PubMed [journal] PMID:


20. Metabolic and kinetic analyses of influenza production in perfusion HEK293 cell

culture. BMC biotechnology. 2011; 11:84. PubMed [journal] PMID: 21884612

21. Manufacturing of adenovirus vectors: production and purification of helper

dependent adenovirus. Methods in molecular biology (Clifton, N.J.). 2011;

737:139-56. PubMed [journal] PMID: 21590396

22. Overview of current scalable methods for purification of viral vectors. Methods

in molecular biology (Clifton, N.J.). 2011; 737:89-116. PubMed [journal] PMID:


23. Development and validation of a HPLC method for the quantification of

baculovirus particles. Journal of chromatography. B, Analytical technologies in

the biomedical and life sciences. 2011; 879(1):61-8. PubMed [journal] PMID:


24. Effect of surface charge on the cellular uptake and cytotoxicity of fluorescent

labeled cellulose nanocrystals. ACS applied materials & interfaces. 2010;

2(10):2924-32. PubMed [journal] PMID: 20919683

25. Bioprocessing of baculovirus vectors: a review. Current gene therapy. 2010;

10(3):174-86. PubMed [journal] PMID: 20380645

26. Scalable production of influenza virus in HEK-293 cells for efficient vaccine

manufacturing. Vaccine. 2010; 28(21):3661-71. PubMed [journal] PMID: 20347632

27. An efficient process for the purification of helper-dependent adenoviral vector

and removal of helper virus by iodixanol ultracentrifugation. Journal of

virological methods. 2010; 165(1):83-9. PubMed [journal] PMID: 20116403

28. Improving adeno-associated vector yield in high density insect cell cultures.

The journal of gene medicine. 2010; 12(2):157-67. PubMed [journal] PMID: 20101623

29. Reassessing culture media and critical metabolites that affect adenovirus

production. Biotechnology progress. 2010; 26(1):200-7. PubMed [journal] PMID:


30. New protocol for lentiviral vector mass production. Methods in molecular

biology (Clifton, N.J.). 2010; 614:39-52. PubMed [journal] PMID: 20225034

31. Development of a simple and high-yielding fed-batch process for the production

of influenza vaccines. Vaccine. 2009; 28(2):309-16. PubMed [journal] PMID:


32. Development of a scalable process for high-yield lentiviral vector production

by transient transfection of HEK293 suspension cultures. The journal of gene

medicine. 2009; 11(10):868-76. PubMed [journal] PMID: 19618482

33. Efficient human hematopoietic cell transduction using RD114- and

GALV-pseudotyped retroviral vectors produced in suspension and serum-free media.

Human gene therapy. 2009; 20(9):966-74. PubMed [journal] PMID: 19453219

34. Probing inhibitory effects of destruxins from Metarhizium anisopliae using

insect cell based impedance spectroscopy: inhibition vs chemical structure. The

Analyst. 2009; 134(7):1447-52. PubMed [journal] PMID: 19562214

35.  Identification of critical infection parameters to control helper-dependent

adenoviral vector production. Journal of biotechnology. 2009; 142(2):142-50.

PubMed [journal] PMID: 19501266

36. From the first to the third generation adenoviral vector: what parameters are

governing the production yield? Biotechnology advances. 2009; 27(2):133-44.

PubMed [journal] PMID: 19013226

37. An efficient and scalable process for helper-dependent adenoviral vector

production using polyethylenimine-adenofection. Biotechnology and bioengineering.

2009; 102(3):800-10. PubMed [journal] PMID: 18821637

Please see MEDLINE indexed publications for a more comprehensive listing

Department of Bioengineering

McDonald Engineering Building

817 Sherbrooke Street West, room 387

Montreal, Quebec, H3A0C3

Phone 514.398.5775