M. Perrier

Latest

• An efficient process for the purification of helper-dependent adenoviral vector and removal of helper virus by iodixanol ultracentrifugation
• An efficient and scalable process for helper-dependent adenoviral vector production using polyethylenimine-adenofection
• From the first to the third generation adenoviral vector: What parameters are governing the production yield?
• Identification of critical infection parameters to control helper-dependent adenoviral vector production
• Critical assessment of current adeno-associated viral vector production and quantification methods
• Improving AAV vector yield in insect cells by modulating the temperature after infection
• Monitoring the physiological state of mammalian cell perfusion processes by on-line estimation of intracellular fluxes
• Multivariable nonlinear control of biomass and metabolite concentrations in a high-cell-density perfusion bioreactor
• Production of adeno-associated viral vectors in insect cells using triple infection: Optimization of baculovirus concentration ratios
• Use of cell bleed in a high cell density perfusion culture and multivariable control of biomass and metabolite concentrations
• Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors
• Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures
• Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus
• 293SF metabolic flux analysis during cell growth and infection with an adenoviral vector
• Human 293 cell metabolism in low glutamine-supplied culture: Interpretation of metabolic changes through metabolic flux analysis
• Adaptive control at low glucose concentration of HEK-293 cell serum-free cultures