functional genomics

From functional genomics of vero cells to CRISPR-based genomic deletion for improved viral production rates

Despite their wide use in the vaccine manufacturing field for over 40 years, one of the main limitations to recent efforts to develop Vero cells as high-throughput vaccine manufacturing platforms is the lack of understanding of virus-host …

Overview of recent advances in Vero cells genomic characterization and engineering for high-throughput vaccine manufacturing

Abstract Background The Vero cell line is the most used continuous cell line for viral vaccine manufacturing with more than 30 years of accumulated experience in the vaccine industry. Nonetheless, virus production yield with Vero cells remains …